A case of incidentally discovered subclinical cushing syndrome in a patient with chronic fatigue and anxiety.

[adrenal incidentaloma]

Subclinical Cushing syndrome (SCS ) is a hypothalamic -pituitary -adrenal axis abnormality characterized by autonomous cortisol secretion in patients with no typical signs or symptoms of Cushing syndrome . SCS patients may have adverse metabolic and cardiovascular effects due to slight , but continuous glucocorticoid secretion . Glucocorticoids also affect behavior , mood , neural activity , and a number of specific biochemical processes in the central nervous system . Here , we report a case of SCS due to an adrenal incidentaloma in a hypertensive diabetic patient who presented with chronic fatigue and anxiety that disappeared after the removal of the adrenal adenoma .