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Severe combined immunodeficiency mouse-psoriatic human skin xenograft model: a modern tool connecting bench to bedside.
[severe combined immunodeficiency]
Psoriasis
is
a
multifactorial
chronic
inflammatory
disease
.
Research
into
the
pathogenesis
of
this
disease
is
hindered
by
the
lack
of
a
proper
animal
model
.
Over
the
past
two
decades
,
many
scientists
were
involved
in
the
development
of
animal
models
that
nearly
mirror
the
immunopathogenesis
of
psoriasis
.
One
such
model
,
which
has
opened
doors
to
the
study
of
molecular
complexities
of
psoriasis
as
well
as
its
treatment
,
is
the
severe
combined
immunodeficiency
(
SCID
)
mouse-human
skin
chimera
model
.
This
model
not
only
mirrors
the
clinical
and
histopathological
features
of
psoriasis
but
also
help
in
the
study
of
cell
proliferation
,
angiogenesis
,
function
of
T
cells
,
neurogenic
inflammation
and
cytokines
involved
in
inflammatory
reactions
.
In
this
article
,
we
have
reviewed
the
prospects
and
the
limitations
of
the
SCID
mouse
model
of
psoriasis
.
