Dystrophic epidermolysis bullosa in goats.

[dystrophic epidermolysis bullosa]

Clinical , histopathological and ultrastructural findings of caprine dystrophic epidermolysis bullosa (DEB ) with autosomal recessive inheritance are reported . The goats presented with exungulation , erosions , crusts and scars on the skin and ulcers in the oral cavity . Microscopically , the skin showed subepidermal separation with clefts filled occasionally with clear eosinophilic fluid , cellular debris or neutrophils . Ultrastructurally , the site of blister formation was the sublamina densa in the epidermal basement membrane zone . In skin with blister formation and in clinically uninvolved skin , the basal lamina was preserved , but the anchoring fibrils were sparse and rudimentary . A twin brother of an affected kid was mated over 5 years with his mother ; three out of the 10 kids born presented with epidermolysis bullosa , indicating that the disease has an autosomal recessive mode of inheritance . It is suggested that the disease is similar to human severe generalized recessive DEB .

Diseases
Validation

Diseases presenting "oral cavity" symptom

cowden syndrome

dedifferentiated liposarcoma

dentinogenesis imperfecta

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

junctional epidermolysis bullosa

kabuki syndrome

kindler syndrome

lamellar ichthyosis

oral submucous fibrosis

papillon-lefèvre syndrome

pleomorphic liposarcoma

proteus syndrome

sneddon syndrome

well-differentiated liposarcoma

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