Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Current and emerging treatments for the management of osteogenesis imperfecta.
[dentinogenesis imperfecta]
Osteogenesis
imperfecta
(
OI
)
is
the
most
common
bone
genetic
disorder
and
it
is
characterized
by
bone
brittleness
and
various
degrees
of
growth
disorder
.
Clinical
severity
varies
widely
;
nowadays
eight
types
are
distinguished
and
two
new
forms
have
been
recently
described
although
not
yet
classified
.
The
approach
to
such
a
variable
and
heterogeneous
disease
should
be
global
and
therefore
multidisciplinary
.
For
simplicity
,
the
objectives
of
treatment
can
be
reduced
to
three
typical
situations
:
the
lethal
perinatal
form
(
type
II
)
,
in
which
the
problem
is
survival
at
birth
;
the
severe
and
moderate
forms
(
types
III
-IX
)
,
in
which
the
objective
is
'
autonomy
'
;
and
the
mild
form
(
type
I
)
,
in
which
the
aim
is
to
reach
'
normal
life
'
.
Three
types
of
treatment
are
available
:
non-surgical
management
(
physical
therapy
,
rehabilitation
,
bracing
and
splinting
)
,
surgical
management
(
intramedullary
rod
positioning
,
spinal
and
basilar
impression
surgery
)
and
medical-pharmacological
management
(
drugs
to
increase
the
strength
of
bone
and
decrease
the
number
of
fractures
as
bisphosphonates
or
growth
hormone
,
depending
on
the
type
of
OI
)
.
Suggestions
and
guidelines
for
a
therapeutic
approach
are
indicated
and
updated
with
the
most
recent
findings
in
OI
diagnosis
and
treatment
.
Diseases
Validation
Diseases presenting
"and updated with the most recent findings in oi diagnosis"
symptom
dentinogenesis imperfecta
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom
