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The fine tuning role of microRNA-RNA interaction in odontoblast differentiation and disease.
[dentinogenesis imperfecta]
Dentinogenesis
imperfecta
and
dentin
dysplasia
are
two
common
types
of
genetic
oral
diseases
resulted
from
the
aberrant
differentiation
of
odontoblast
.
Understanding
the
mechanisms
of
odontoblast
differentiation
is
crucial
for
finding
the
diagnosis
candidate
genes
and
treatment
targets
for
such
kinds
of
diseases
.
Previous
work
has
identified
a
battery
of
transcription
factors
and
growth
factors
regulating
odontoblast
differentiation
;
however
,
the
post-transcriptional
regulating
mechanisms
of
them
are
poorly
studied
.
MicroRNAs
(
miRNA
)
are
a
group
of
non-coding
RNAs
widely
studied
in
organ
development
,
inflammation
,
and
tumorigenesis
because
of
its
inhibitory
effects
on
the
target
mRNAs
.
Also
,
miRNAs
along
with
their
binding
targets
form
a
complex
competing
endogenous
RNA
(
ceRNA
)
network
where
miRNAs
serve
as
the
fine
tuning
balancers
between
their
targets
.
Recent
reports
demonstrated
the
essential
role
of
the
miRNA
pathway
in
dentinogenesis
and
the
regulatory
role
of
several
specific
miRNAs
in
the
in
vitro
model
of
odontoblast
differentiation
.
Herein
,
we
will
discuss
the
general
roles
of
miRNA
in
diseases
,
the
function
of
miRNAs
during
odontoblast
differentiation
,
and
finally
the
potential
pathological
mechanisms
through
which
miRNAs
cause
the
odontoblast-related
diseases
.
