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Omalizumab as a desensitizing agent and treatment in mastocytosis: a review of the literature and case report.
[cutaneous mastocytosis]
Patients
with
all
forms
of
mastocytosis
can
experience
urticaria
,
abdominal
cramps
,
nausea
,
diarrhea
,
or
hypotension
due
to
release
of
mediators
by
mast
cells
.
Patients
with
mastocytosis
and
Hymenoptera
venom
allergy
can
develop
severe
adverse
reactions
to
Hymenoptera
stings
.
In
addition
,
patients
with
mastocytosis
and
on
venom
immunotherapy
are
at
high
risk
for
incomplete
protection
and
fatal
reactions
.
Recent
literature
has
reported
the
use
of
omalizumab
as
an
adjunctive
treatment
in
patients
with
mastocytosis
,
used
for
both
symptom
improvement
and
to
dampen
adverse
effects
caused
by
venom
immunotherapy
.
This
article
reviews
the
literature
regarding
omalizumab
use
in
the
treatment
of
mastocytosis
and
for
protection
against
the
adverse
effects
during
venom
immunotherapy
.
In
addition
,
we
report
the
case
of
a
patient
at
high
risk
and
with
cutaneous
mastocytosis
,
whose
symptoms
improved
with
concomitant
administration
of
omalizumab
and
venom
immunotherapy
.
