Tissue engineering in congenital diaphragmatic hernia.

[congenital diaphragmatic hernia]

Engineered diaphragmatic repair is emblematic of perinatal regenerative medicine and of the fetal tissue engineering concept . The alternative of a cellularized graft for the repair of a congenital diaphragmatic defect in the neonatal period is both biologically justifiable by the mechanisms behind diaphragmatic hernia recurrence as well as an ideal match for fetal mesenchymal stem cell-based constructs . It has been among the most developed experimental pursuits in neonatal tissue engineering , of which clinical application should be forthcoming .