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Plasma gelsolin as a biomarker of acute rheumatic carditis.
[acute rheumatic fever]
Acute
rheumatic
fever
is
an
autoimmune
,
inflammatory
,
and
multi-systemic
disease
secondary
to
pharyngitis
and
is
caused
by
group
A
streptococcus
.
In
developing
countries
,
acute
rheumatic
fever
is
the
most
common
cause
of
acquired
heart
disease
.
Gelsolin
is
a
calcium
-dependent
,
multi-
functional
actin-regulatory
protein
circulating
in
the
plasma
of
healthy
human
beings
.
The
correlation
between
blood
gelsolin
levels
and
inflammatory
conditions
suggests
the
potential
benefit
of
gelsolin
as
a
prognostic
marker
.
The
aim
of
the
present
study
was
to
appraise
the
association
of
gelsolin
and
acute
rheumatic
carditis
in
childhood
.
Materials
and
Methods
Plasma
gelsolin
levels
were
measured
and
echocardiographic
examinations
were
performed
in
patients
(
n
=
37
)
with
acute
rheumatic
carditis
and
compared
with
those
of
age-
and
gender-matched
healthy
controls
(
n
=
24
)
.
The
plasma
gelsolin
levels
in
children
with
acute
rheumatic
carditis
were
significantly
lower
compared
with
controls
(
197
±
218
versus
322
±
255
mg
/
L
,
p
=
0
.
039
)
.
There
was
a
significant
correlation
among
gelsolin
levels
and
the
grade
of
mitral
regurgitation
(
p
=
0
.
030
)
,
left
ventricular
end-diastolic
diameter
(
p
=
0
.
017
)
,
and
left
ventricular
end-systolic
diameter
(
p
=
0
.
028
)
at
diagnosis
.
Levels
of
the
gelsolin
plasma
isoform
were
decreased
in
patients
with
acute
rheumatic
carditis
compared
with
healthy
controls
.
Gelsolin
may
be
used
as
a
biochemical
marker
for
acute
rheumatic
carditis
.
Diseases
Validation
Diseases presenting
"acquired heart disease"
symptom
acute rheumatic fever
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