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The Effect of Metformin on Androgen Production in Diabetic Women with Non-classic Congenital Adrenal Hyperplasia.
[congenital adrenal hyperplasia]
Non-classic
congenital
adrenal
hyperplasia
(
NC-
CAH
)
,
one
of
the
most
common
genetic
disorders
,
is
often
associated
with
the
clinical
features
of
hyperandrogenism
.
This
study
included
19
women
with
recently
diagnosed
and
previously
untreated
type
2
diabetes
,
8
of
whom
suffered
from
NC-
CAH
,
treated
with
metformin
(
2
.
55
-
3
.
0
 
g
daily
)
.
Glucose
homeostasis
markers
,
plasma
lipids
,
as
well
as
plasma
levels
of
17
-
hydroxyprogesterone
,
androgens
and
gonadotropins
were
assessed
at
baseline
and
after
6
months
of
therapy
.
In
both
groups
of
patients
,
metformin
reduced
fasting
plasma
glucose
,
insulin
resistance
,
triglycerides
and
glycated
hemoglobin
.
Moreover
,
in
patients
with
NC-
CAH
,
but
not
in
women
with
normal
adrenal
function
,
metformin
decreased
plasma
levels
of
17
-
hydroxyprogesterone
,
total
and
free
testosterone
,
androstenedione
and
dehydroepiandrosterone
sulphate
.
The
obtained
results
suggest
that
metformin
partially
normalizes
androgen
production
in
symptomatic
patients
with
NC-
CAH
.
Diseases
Validation
Diseases presenting
"congenital adrenal hyperplasia"
symptom
adrenal incidentaloma
aromatase deficiency
congenital adrenal hyperplasia
cushing syndrome
phenylketonuria
This symptom has already been validated
