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Sustained attention in untreated non-PKU-hyperphenylalaninemia.
[classical phenylketonuria]
Twenty
-
four
untreated
adolescent
and
adult
patients
with
non-
PKU
hyperphenylalaninemia
(
HPA
)
(
serum
Phe
levels
<
600
mumol
/
L
)
and
24
healthy
controls
matched
for
age
,
sex
,
and
IQ
were
investigated
for
simple
motor
reaction
time
and
sustained
attention
,
which
are
prolonged
in
patients
with
mild
or
classical
phenylketonuria
(
PKU
)
.
Patients
with
HPA
were
of
normal
intelligence
and
did
not
differ
significantly
from
healthy
controls
in
their
test
results
.
For
HPA
patients
,
reaction
times
and
sustained
attention
were
not
significantly
influenced
by
serum
phenylalanine
concentrations
.
We
conclude
that
dietary
treatment
is
not
necessary
in
patients
with
non-
PKU
HPA
.