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Outcomes following resection of intrahepatic cholangiocarcinoma.
[cholangiocarcinoma]
The
aim
of
this
analysis
was
to
examine
prognostic
features
and
outcomes
in
patients
undergoing
resection
for
intrahepatic
cholangiocarcinoma
(
ICC
)
.
A
retrospective
chart
review
was
performed
in
all
patients
who
underwent
R
0
or
R
1
resection
for
primary
ICC
between
1995
and
2011
.
Clinical
data
were
abstracted
and
statistical
analyses
were
conducted
in
the
standard
fashion
.
A
total
of
82
patients
underwent
curative
hepatectomy
for
primary
ICC
;
51
patients
in
this
cohort
developed
recurrence
.
The
median
follow-up
of
survivors
was
27
months
(
range
:
1
-
116
months
)
.
Recurrences
were
intrahepatic
(
65
%
)
,
associated
with
multiple
tumours
(
54
%
)
and
occurred
during
the
first
2
years
after
hepatectomy
(
86
%
)
.
The
main
factor
associated
with
recurrence
after
resection
was
the
presence
of
satellite
lesions
.
Overall
5
-
year
disease-free
survival
after
primary
resection
was
16
%
.
Factors
associated
with
poor
survival
were
transfusion
and
perineural
invasion
.
Treatment
of
recurrence
was
undertaken
in
89
%
of
patients
and
repeat
surgical
resection
was
performed
in
15
patients
.
The
3
-
year
survival
rate
after
recurrence
was
25
%
.
Prolonged
survival
after
recurrence
was
associated
with
a
solitary
tumour
recurrence
.
Despite
curative
resection
of
ICC
,
recurrence
can
be
expected
to
occur
in
79
%
of
patients
at
5
years
.
Predictors
of
survival
and
recurrence
after
resection
vary
in
the
literature
.
In
patients
with
recurrence
,
selection
of
the
optimal
treatment
remains
challenging
.
Diseases
Validation
Diseases presenting
"prolonged survival"
symptom
alexander disease
cholangiocarcinoma
harlequin ichthyosis
hodgkin lymphoma, classical
krabbe disease
megacystis-microcolon-intestinal hypoperistalsis syndrome
neonatal adrenoleukodystrophy
primary effusion lymphoma
pyruvate dehydrogenase deficiency
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