Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Brain fluorodeoxyglucose PET in adrenoleukodystrophy.
[x-linked adrenoleukodystrophy]
To
investigate
the
cerebral
glucose
metabolism
in
subjects
with
X-
linked
adrenoleukodystrophy
(
X-
ALD
)
by
using
brain
[
(
18
)
F
]
-
fluorodeoxyglucose
PET
(
FDG-PET
)
.
Cross-sectional
study
in
which
12
adults
with
various
forms
of
X-
ALD
underwent
clinical
evaluation
and
brain
MRI
,
followed
by
brain
FDG-PET
,
neuropsychological
assessment
,
and
personality
and
psychopathology
evaluation
using
the
Symptom
Checkist-
90
-
Revised
(
SCL-
90
-
R
)
and
the
Millon
Clinical
Multiaxial
Inventory-
III
(
MCMI-
III
)
.
When
compared
to
healthy
control
subjects
(
n
=
27
)
by
using
Statistical
Parametric
Mapping
8
software
,
the
patients
with
X-
ALD
-with
or
without
brain
MRI
changes
-showed
a
pattern
of
increased
glucose
metabolism
in
frontal
lobes
and
reduced
glucose
metabolism
in
cerebellum
and
temporal
lobe
areas
.
On
single
case
analysis
by
Scenium
software
,
we
found
a
similar
pattern
,
with
significant
(
p
<
0
.
02
)
correlation
between
the
degree
of
hypermetabolism
in
the
frontal
lobes
of
each
patient
and
the
corresponding
X-
ALD
clinical
scores
.
With
respect
to
personality
,
we
found
that
patients
with
X-
ALD
usually
present
with
an
obsessive-compulsive
personality
disorder
on
the
MCMI-
III
,
with
significant
(
p
<
0
.
05
)
correlation
between
glucose
uptake
in
ventral
striatum
and
severity
of
score
on
the
obsessive-compulsive
subscale
.
We
examined
cerebral
glucose
metabolism
using
FDG-PET
in
a
cohort
of
patients
with
X-
ALD
and
provided
definite
evidence
that
in
X-
ALD
the
analysis
of
brain
glucose
metabolism
reveals
abnormalities
independent
from
morphologic
and
signal
changes
detected
by
MRI
and
related
to
clinical
severity
.
Brain
FDG-PET
may
be
a
useful
neuroimaging
technique
for
the
characterization
of
X-
ALD
and
possibly
other
leukodystrophies
.