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The stability of hexacosanoyl lysophosphatidylcholine in dried-blood spot quality control materials for X-linked adrenoleukodystrophy newborn screening.
[x-linked adrenoleukodystrophy]
Newborn
screening
for
X-
linked
adrenoleukodystrophy
utilizes
tandem
mass
spectrometry
to
analyze
dried-
blood
spot
specimens
.
Quality
control
materials
(
dried-
blood
spots
enriched
with
hexacosanoyl
lysophosphatidylcholine
)
were
prepared
and
stored
at
different
temperatures
for
up
to
518
days
to
evaluate
the
stability
of
this
biomarker
for
X-
linked
adrenoleukodystrophy
.
Dried-
blood
spot
storage
included
desiccant
(
45
,
171
,
and
518
days
)
or
omitted
desiccant
(
53
days
at
>
90
%
relative
humidity
)
.
Specimens
were
stored
for
171
and
518
days
at
-
20
°
C
,
4
°
C
,
ambient
temperature
,
and
37
°
C
.
Each
weekday
for
45
days
,
a
bag
of
specimens
stored
at
4
°
C
was
warmed
to
ambient
temperature
and
one
specimen
was
removed
for
storage
at
-
80
°
C
.
Specimens
were
analyzed
by
high
-performance
liquid-chromatography
electrospray
ionization
tandem
mass
spectrometry
and
data
was
plotted
as
concentration
(
micromoles
per
liter
)
vs
.
time
.
Linear
regression
provided
slope
and
y-intercept
values
for
each
storage
condition
.
Small
slope
values
(
0
.
01
or
less
)
and
y-intercept
values
close
to
the
enrichment
indicated
less
than
11
%
loss
of
hexacosanoyl
lysophosphatidylcholine
under
all
storage
conditions
tested
.
Quality
control
materials
for
X-
linked
adrenoleukodystrophy
are
stable
for
at
least
1
year
when
stored
with
desiccant
.