Two successive pregnancies in a woman with xanthinuria: unexpected increase in serum uric acid levels.

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Two successive pregnancies were observed in a patient with xanthinuria . In each of them , maternal serum uric acid (SUA ) level rose progressively during the third trimester , reaching a subnormal value just before delivery . The level of UA was slightly higher in arterial cord blood than in maternal blood . There was no difference between levels in arterial and venous cord blood . It is suggested that xanthine oxydase may be present in the placenta .