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The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.
[wolf-hirschhorn syndrome]
Histone
lysine
methylation
plays
a
fundamental
role
in
chromatin
organization
.
Although
a
set
of
histone
methyltransferases
have
been
identified
and
biochemically
characterized
,
the
pathological
roles
of
their
dysfunction
in
human
cancers
are
still
not
well
understood
.
In
this
study
,
we
demonstrate
important
roles
of
WHSC
1
L
1
in
human
carcinogenesis
.
Expression
levels
of
WHSC
1
L
1
transcript
were
significantly
elevated
in
various
human
cancers
including
bladder
carcinoma
.
Immunohistochemical
analysis
of
bladder
,
lung
,
and
liver
cancers
confirmed
overexpression
of
WHSC
1
L
1
.
WHSC
1
L
1
-
specific
small
interfering
RNAs
significantly
knocked
down
its
expression
and
resulted
in
suppression
of
proliferation
of
bladder
and
lung
cancer
cell
lines
.
WHSC
1
L
1
knockdown
induced
cell
cycle
arrest
at
the
G
(
2
)
/
M
phase
followed
by
multinucleation
of
cancer
cells
.
Expression
profile
analysis
using
Affymetrix
GeneChip
(
®
)
showed
that
WHSC
1
L
1
affected
the
expression
of
a
number
of
genes
including
CCNG
1
and
NEK
7
,
which
are
known
to
play
crucial
roles
in
the
cell
cycle
progression
at
mitosis
.
As
WHSC
1
L
1
expression
is
significantly
low
in
various
normal
tissues
including
vital
organs
,
WHSC
1
L
1
could
be
a
good
candidate
molecule
for
development
of
novel
treatment
for
various
types
of
cancer
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated