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Oestrogen modulation of the effect of 8-OH-DPAT on prepulse inhibition: effects of aromatase deficiency and castration in mice.
[aromatase deficiency]
The
aim
of
this
study
was
to
investigate
the
interaction
of
sex
steroid
hormones
,
particularly
oestrogen
,
in
the
regulation
of
prepulse
inhibition
(
PPI
)
by
serotonin-
1
A
(
5
-
HT
1
A
)
receptors
.
We
studied
aromatase
knockout
(
ArKO
)
mice
,
which
are
unable
to
produce
oestrogen
but
have
high
levels
of
testosterone
,
and
the
effects
of
castration
.
Treatment
of
male
ArKO
mice
with
the
5
-
HT
1
A
receptor
agonist
,
8
-
hydroxy-dipropyl-aminotetralin
(
8
-
OH
-DPAT
)
,
caused
an
increase
in
PPI
that
was
significantly
greater
than
in
male
wild-
type
controls
.
Castration
of
male
mice
caused
a
significant
enhancement
of
the
effect
of
8
-
OH
-DPAT
in
control
mice
;
however
,
there
was
no
change
in
the
effect
of
this
drug
in
ArKO
mice
.
There
was
no
significant
effect
of
8
-
OH
-DPAT
on
PPI
in
either
female
ArKO
or
wild-
type
controls
.
In
all
experiments
,
the
effects
of
8
-
OH
-DPAT
on
startle
were
not
different
between
the
groups
.
[
3
H
]
8
-
OH
-DPAT
autoradiography
showed
no
differences
in
5
-
HT
1
A
receptor
binding
densities
in
areas
of
the
forebrain
,
hippocampus
or
raphe
region
that
could
explain
the
PPI
results
.
These
data
show
that
the
absence
of
oestrogen
in
male
ArKO
mice
leads
to
a
greater
effect
of
5
-
HT
1
A
receptor
stimulation
on
PPI
.
This
effect
can
be
mimicked
in
male
control
mice
by
castration
.
The
differential
involvement
of
oestrogen
and
testosterone
in
these
animal
models
is
discussed
.
Diseases
Validation
Diseases presenting
"high levels"
symptom
22q11.2 deletion syndrome
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
alpha-thalassemia
aromatase deficiency
cadasil
canavan disease
classical phenylketonuria
congenital adrenal hyperplasia
congenital toxoplasmosis
cutaneous mastocytosis
cystinuria
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
erythropoietic protoporphyria
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
holt-oram syndrome
homocystinuria without methylmalonic aciduria
kabuki syndrome
kallmann syndrome
liposarcoma
papillon-lefèvre syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
scrub typhus
severe combined immunodeficiency
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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