Rare Diseases Symptoms Automatic Extraction

NK/DC crosstalk in immunosurveillance: a broken relationship caused by WASP-deficiency.

[wiskott-aldrich syndrome]

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency, which is characterized by abnormal immune system functions caused by the lack of expression of WAS protein (WASp). A higher tumor susceptibility is observed in WAS patients; whether this is a direct consequence of impaired immunosurveillance due to WAS deficiency in immune cells is, however, an open question. In this issue of the European Journal of Immunology, Catucci et al. [Eur. J. Immunol. 2014. 44: 1039-1045] shed light on the link between Was deficiency and immunosurveillance in a tumor-prone mouse model and report a role for the impaired crosstalk between natural killer (NK) cells and dendritic cells (DCs) in mediating this process. The potential mechanisms involved in WASp regulation of NK/DC-mediated immunosurveillance are the focus of this Commentary.

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  • adrenal incidentaloma
  • alexander disease
  • alpha-thalassemia
  • aromatase deficiency
  • benign recurrent intrahepatic cholestasis
  • cushing syndrome
  • dedifferentiated liposarcoma
  • dracunculiasis
  • dystrophic epidermolysis bullosa
  • esophageal carcinoma
  • focal myositis
  • heparin-induced thrombocytopenia
  • hodgkin lymphoma, classical
  • hydrocephalus with stenosis of the aqueduct of sylvius
  • junctional epidermolysis bullosa
  • krabbe disease
  • lamellar ichthyosis
  • megacystis-microcolon-intestinal hypoperistalsis syndrome
  • monosomy 21
  • neuralgic amyotrophy
  • oculocutaneous albinism
  • omenn syndrome
  • primary hyperoxaluria type 1
  • pyruvate dehydrogenase deficiency
  • sneddon syndrome
  • thoracic outlet syndrome
  • von hippel-lindau disease
  • wiskott-aldrich syndrome
  • x-linked adrenoleukodystrophy

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