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BAR domain proteins regulate Rho GTPase signaling.
[wiskott-aldrich syndrome]
BAR
proteins
comprise
a
heterogeneous
group
of
multi-domain
proteins
with
diverse
biological
functions
.
The
common
denominator
is
the
Bin-
Amphiphysin-
Rvs
(
BAR
)
domain
that
not
only
confers
targeting
to
lipid
bilayers
,
but
also
provides
scaffolding
to
mold
lipid
membranes
into
concave
or
convex
surfaces
.
This
function
of
BAR
proteins
is
an
important
determinant
in
the
dynamic
reconstruction
of
membrane
vesicles
,
as
well
as
of
the
plasma
membrane
.
Several
BAR
proteins
function
as
linkers
between
cytoskeletal
regulation
and
membrane
dynamics
.
These
links
are
provided
by
direct
interactions
between
BAR
proteins
and
actin-nucleation-promoting
factors
of
the
Wiskott-
Aldrich
syndrome
protein
family
and
the
Diaphanous-related
formins
.
The
Rho
GTPases
are
key
factors
for
orchestration
of
this
intricate
interplay
.
This
review
describes
how
BAR
proteins
regulate
the
activity
of
Rho
GTPases
,
as
well
as
how
Rho
GTPases
regulate
the
function
of
BAR
proteins
.
This
mutual
collaboration
is
a
central
factor
in
the
regulation
of
vital
cellular
processes
,
such
as
cell
migration
,
cytokinesis
,
intracellular
transport
,
endocytosis
,
and
exocytosis
.
