Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.
[wiskott-aldrich syndrome]
Membrane
protrusions
at
the
leading
edge
of
cells
,
known
as
lamellipodia
,
drive
cell
migration
in
many
normal
and
pathological
situations
.
Lamellipodial
protrusion
is
powered
by
actin
polymerization
,
which
is
mediated
by
the
actin-related
protein
2
/
3
(
ARP
2
/
3
)
-
induced
nucleation
of
branched
actin
networks
and
the
elongation
of
actin
filaments
.
Recently
,
advances
have
been
made
in
our
understanding
of
positive
and
negative
ARP
2
/
3
regulators
(
such
as
the
SCAR
/
WAVE
(
SCAR
/
WASP
family
verprolin-homologous
protein
)
complex
and
Arpin
,
respectively
)
and
of
proteins
that
control
actin
branch
stability
(
such
as
glial
maturation
factor
(
GMF
)
)
or
actin
filament
elongation
(
such
as
ENA
/
VASP
proteins
)
in
lamellipodium
dynamics
and
cell
migration
.
This
Review
highlights
how
the
balance
between
actin
filament
branching
and
elongation
,
and
between
the
positive
and
negative
feedback
loops
that
regulate
these
activities
,
determines
lamellipodial
persistence
.
Importantly
,
directional
persistence
,
which
results
from
lamellipodial
persistence
,
emerges
as
a
critical
factor
in
steering
cell
migration
.
Diseases
Validation
Diseases presenting
"the elongation of actin filaments"
symptom
wiskott-aldrich syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom