Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome.

[werner syndrome]

Minor inflammation -driven aging (inflammaging ) has been proposed to explain human aging mechanism . To study the inflammatory condition associated with normal human aging , highly sensitive CRP (hsCRP ) was examined in the sera collected from 217 healthy Japanese individuals aged between 1 and 100 years and 41 mutation -proven Japanese Werner syndrome (WS ) patients . The serum hsCRP was assayed by ELISA . The serum hsCRP level increased significantly (p <0 .001 ) with normal aging from both sexes . The serum hsCRP was significantly elevated in WS (mean ±SE : 11 .0 ±1 .6 μg /ml ) compared with age-matched normal population (1 .3 ±0 .3 μg /ml , p <0 .001 ) and normal elderly population ages between 71 and 100 years (4 .2 ±0 .7 μg /ml , p <0 .001 ). Both normal aging and WS were associated with minor inflammation that can be evaluated by serum hsCRP . WS may be a good candidate to study inflammaging .