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The epidemiology of premature aging and associated comorbidities.
[werner syndrome]
Hutchinson
-
Gilford
Progeria
Syndrome
and
Werner
syndrome
,
also
known
as
childhood-
and
adulthood-
progeria
,
respectively
,
represent
two
of
the
best
characterized
human
progeroid
diseases
with
clinical
features
mimicking
physiological
aging
at
an
early
age
.
The
discovery
of
their
genetic
basis
has
led
to
the
identification
of
several
gene
mutations
leading
to
a
spectrum
of
progeroid
phenotypes
ranging
from
moderate
and
mild
-
severe
to
very
aggressive
forms
.
In
parallel
,
the
creation
of
disease
registers
and
databases
provided
available
data
for
the
design
of
relatively
large
-scale
epidemiological
studies
,
thereby
allowing
a
better
understanding
of
the
nature
and
frequency
of
the
premature
aging-associated
signs
and
symptoms
.
The
aim
of
this
article
is
to
review
the
most
recent
findings
concerning
the
epidemiology
of
premature
aging
disorders
,
their
genetic
basis
,
and
the
most
recent
reports
on
the
frequency
of
associated
diseases
.
