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Genetics of aging, progeria and lamin disorders.
[werner syndrome]
Premature
aging
disorders
,
like
Werner
syndrome
,
Bloom
's
syndrome
,
and
Hutchinson
-
Gilford
Progeria
Syndrome
(
HGPS
)
,
have
been
the
subjects
of
immense
interest
as
they
recapitulate
many
of
the
phenotypes
observed
in
physiological
aging
.
They
,
therefore
,
not
only
provide
model
systems
to
study
normal
aging
processes
but
also
give
valuable
insights
into
the
intricate
mechanisms
underlying
senescence
.
Recent
works
on
HGPS
have
revealed
alterations
in
a
spectrum
of
cellular
and
molecular
pathways
involved
in
the
maintenance
of
genomic
integrity
,
thus
suggesting
a
profound
impact
of
the
nuclear
lamina
in
nuclear
organization
,
chromatin
dynamics
,
regulation
of
gene
expression
and
epigenetics
.
Diseases
Validation
Diseases presenting
"profound impact of the nuclear lamina in nuclear organization"
symptom
werner syndrome
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