Genetics of aging, progeria and lamin disorders.

[werner syndrome]

Premature aging disorders , like Werner syndrome , Bloom 's syndrome , and Hutchinson -Gilford Progeria Syndrome (HGPS ), have been the subjects of immense interest as they recapitulate many of the phenotypes observed in physiological aging . They , therefore , not only provide model systems to study normal aging processes but also give valuable insights into the intricate mechanisms underlying senescence . Recent works on HGPS have revealed alterations in a spectrum of cellular and molecular pathways involved in the maintenance of genomic integrity , thus suggesting a profound impact of the nuclear lamina in nuclear organization , chromatin dynamics , regulation of gene expression and epigenetics .