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Carboxypeptidase M in apoptosis, adipogenesis and cancer.
[well-differentiated liposarcoma]
This
review
covers
carboxypeptidase
M
(
CPM
)
research
that
appeared
in
the
literature
since
2009
.
The
focus
is
on
aspects
that
are
new
or
interesting
from
a
clinical
perspective
.
Available
research
tools
are
discussed
as
well
as
their
pitfalls
and
limitations
.
Evidence
is
provided
to
suggest
the
potential
involvement
of
CPM
in
apoptosis
,
adipogenesis
and
cancer
.
This
evidence
derives
from
the
expression
pattern
of
CPM
and
its
putative
substrates
in
cells
and
tissues
.
In
recent
years
CPM
emerged
as
a
potential
cancer
biomarker
,
in
well
differentiated
liposarcoma
where
the
CPM
gene
is
co
-amplified
with
the
oncogene
MDM
2
;
and
in
lung
adenocarcinoma
where
coexpression
with
EGFR
correlates
with
poor
prognosis
.
The
available
data
call
for
extended
investigation
of
the
function
of
CPM
in
tumor
cells
,
tumor
-associated
macrophages
,
stromal
cells
and
tumor
neovascularisation
.
Such
experiments
could
be
instrumental
to
validate
CPM
as
a
therapeutic
target
.
