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A giant mesentery malignant solitary fibrous tumor recurring as dedifferentiated liposarcoma- a report of a very rare case and literature review.
[well-differentiated liposarcoma]
We
report
a
case
of
a
59
-
year
-old
woman
with
a
very
rare
giant
mesentery
malignant
solitary
fibrous
tumor
that
recurred
as
dedifferentiated
liposarcoma
.
The
woman
was
admitted
to
the
hospital
because
of
low
abdominal
pain
.
Radiological
and
biopsy
findings
revealed
a
multi-lobulated
giant
malignant
solitary
fibrous
tumor
that
had
invaded
the
inferior
vena
cava
,
abdominal
aorta
,
and
superior
mesentery
vessels
.
The
tumor
was
completely
removed
during
the
first
cytoreductive
surgery
.
Histopathologically
,
tumor
had
a
heterogeneous
cell
population
,
composed
of
spindle
cells
with
fibrous
collagen
proliferation
.
The
spindle
cells
were
not
arranged
in
a
specific
pattern
.
Immunohistochemistry
revealed
that
the
tumor
cells
were
positive
for
CD
34
,
CD
99
,
Bcl-
2
,
and
smooth
muscle
actin
(
SMA
)
and
negative
for
CD
117
,
epithelial
membrane
antigen
(
EMA
)
,
CAM
5
.
7
,
S
100
,
desmin
,
and
caldesmon
.
The
tumor
recurred
9
months
after
surgery
,
and
another
cytoreductive
surgery
was
then
performed
.
The
postoperative
histopathological
appearance
of
the
invaded
area
indicated
a
well-differentiated
liposarcoma
.
Formation
of
tumorous
bone
was
also
noted
in
the
same
area
,
in
addition
to
atypical
mesenchymal
cells
and
multi-vacuolated
lipoblasts
in
the
area
of
the
well-differentiated
liposarcoma
.
Proliferated
spindle
cells
arranged
in
a
storiform
pattern
were
found
in
the
area
adjacent
to
the
tumor
.
Immunohistochemical
analysis
revealed
that
the
tumors
cells
were
positive
for
SMA
,
HHF-
35
,
and
caldesmon
and
negative
for
CD
117
,
CD
34
,
and
S
100
.
A
diagnosis
of
dedifferentiated
liposarcoma
was
made
.
Diseases
Validation
Diseases presenting
"multi-vacuolated lipoblasts in the area of the well-differentiated liposarcoma"
symptom
dedifferentiated liposarcoma
well-differentiated liposarcoma
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