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Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma.
[well-differentiated liposarcoma]
We
studied
a
series
of
spindle
cell
lipomas
arising
in
atypical
sites
and
showing
unusual
morphologic
features
(
which
we
called
atypical
spindle
cell
lipoma
)
to
assess
if
these
lesions
have
the
same
chromosomal
alterations
as
classical
spindle
cell
lipoma
but
different
from
those
found
in
atypical
lipomatous
tumor
/
well-differentiated
liposarcoma
.
We
investigated
alterations
of
different
genes
in
the
13
q
14
region
and
the
amplification
status
of
the
MDM
2
and
CDK
4
genes
at
12
q
14
-
15
by
multiplex
ligation-dependent
probe
amplification
(
MLPA
)
and
fluorescence
in
situ
hybridization
(
FISH
)
analysis
.
In
the
atypical
spindle
cell
lipomas
,
MLPA
revealed
deletions
in
the
two
nearest
flanking
genes
of
RB
1
(
ITM
2
B
and
RCBTB
2
)
and
in
multiple
important
exons
of
RB
1
.
In
contrast
,
in
classical
spindle
cell
lipomas
,
a
less
complex
loss
of
RB
1
exons
was
found
but
no
deletion
of
ITM
2
B
and
RCBTB
2
.
Moreover
,
MLPA
identified
a
deletion
of
the
DLEU
1
gene
,
a
finding
which
has
not
been
reported
earlier
.
We
propose
an
immunohistochemical
panel
for
lipomatous
tumors
which
comprises
of
MDM
2
,
CDK
4
,
p
16
,
Rb
,
which
we
have
found
useful
in
discriminating
between
atypical
or
classical
spindle
cell
lipomas
and
other
adipocytic
neoplasms
,
especially
atypical
lipomatous
tumor
/
well-differentiated
liposarcoma
.
Our
findings
strengthen
the
link
between
atypical
spindle
cell
lipoma
and
classical
spindle
cell
lipoma
,
and
differentiate
them
from
atypical
lipomatous
tumor
/
well-differentiated
liposarcoma
.
Diseases
Validation
Diseases presenting
"mlpa revealed deletions in the two nearest flanking genes of rb1"
symptom
well-differentiated liposarcoma
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