Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Simultaneous presentation of Waldenström macroglobulinemia and multiple myeloma: multidisciplinary diagnosis, treatment and 30-month follow-up.
[waldenström macroglobulinemia]
Waldenström
macroglobulinemia
and
multiple
myeloma
are
mature
B-
cell
neoplasms
deriving
from
post-germinal
cells
at
different
stages
of
differentiation
.
The
simultaneous
presentation
of
Waldenström
macroglobulinemia
and
multiple
myeloma
in
the
same
patient
is
a
very
rare
phenomenon
and
,
so
far
,
only
two
cases
have
been
described
.
We
report
the
case
of
a
75
-
year
Caucasian
female
patient
,
with
a
silent
clinical
history
,
who
presented
with
anemia
and
two
different
monoclonal
proteins
(
IgM
κ
and
IgG
κ
)
.
The
trephine
biopsy
showed
the
presence
of
a
dual
population
,
represented
by
small
lymphoplasmacytoid
cells
and
by
plasma
cells
,
which
infiltrated
the
bone
marrow
with
a
clearly
different
pattern
.
Both
immunohistochemistry
and
flow
cytometry
demonstrated
the
biclonal
origin
such
neoplastic
cells
,
since
lymphoplasmacytoid
cells
resulted
IgMκ
while
plasma
cells
were
IgG
κ
.
This
biclonal
pattern
was
further
confirmed
by
the
demonstration
of
a
different
IgH
gene
rearrangement
of
the
two
neoplasms
.
The
patient
was
treated
with
bortezomib
,
dexamethasone
and
rituximab
,
achieving
partial
remission
of
both
Waldenström
macroglobulinemia
and
multiple
myeloma
.
After
a
30
-
month
follow-up
,
she
is
in
stable
disease
.
Multiple
myeloma
has
been
described
in
association
with
other
indolent
B-
cell
neoplasms
,
mostly
chronic
lymphocytic
leukemia
,
while
Waldenström
macroglobulinemia
can
be
followed
by
diffuse
large
B-
cell
lymphoma
in
some
instances
,
after
chemotherapy
.
The
association
of
Waldenström
macroglobulinemia
and
multiple
myeloma
seems
to
be
very
rare
.
Our
study
shows
that
an
integrated
diagnostic
work-up
is
very
useful
in
such
cases
,
with
an
interesting
role
for
flow
cytometry
.
[
J
Clin
Exp
Hematop
53
(
1
)
:
29
-
36
,
2013
]
.
Diseases
Validation
Diseases presenting
"female patient"
symptom
achondroplasia
adrenal incidentaloma
alexander disease
aniridia
aromatase deficiency
benign recurrent intrahepatic cholestasis
carcinoma of the gallbladder
coats disease
cohen syndrome
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentinogenesis imperfecta
epidermolysis bullosa simplex
esophageal squamous cell carcinoma
fabry disease
holt-oram syndrome
hydrocephalus with stenosis of the aqueduct of sylvius
kallmann syndrome
kindler syndrome
krabbe disease
lamellar ichthyosis
liposarcoma
lymphangioleiomyomatosis
malignant atrophic papulosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
x-linked adrenoleukodystrophy
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom