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Therapeutic effects of thalidomide in hematologic disorders: a review.
[waldenström macroglobulinemia]
The
extensive
autoimmune
,
anti-
inflammatory
,
and
anticancer
applications
of
thalidomide
have
inspired
a
growing
number
of
studies
and
clinical
trials
.
As
an
inexpensive
agent
with
relatively
low
toxicity
,
thalidomide
is
regarded
as
a
promising
therapeutic
candidate
,
especially
for
malignant
diseases
.
We
review
its
therapeutic
effects
in
hematology
,
including
those
on
multiple
myeloma
,
Waldenstroem
macroglobulinemia
,
lymphoma
,
mantle-cell
lymphoma
,
myelodysplastic
syndrome
,
hereditary
hemorrhagic
telangiectasia
,
and
graftversus-host
disease
.
Most
studies
have
shown
satisfactory
results
,
although
several
have
reported
the
opposite
.
Aside
from
optimal
outcomes
,
the
toxicities
and
adverse
effects
of
thalidomide
should
also
be
examined
.
The
current
work
includes
a
discussion
of
the
mechanisms
through
which
the
novel
biological
effects
of
thalidomide
occur
,
although
more
studies
should
be
devoted
to
this
aspect
.
With
appropriate
safeguards
,
thalidomide
may
benefit
patients
suffering
from
a
broad
variety
of
disorders
,
particularly
refractory
and
resistant
diseases
.
Diseases
Validation
Diseases presenting
"relatively low toxicity"
symptom
waldenström macroglobulinemia
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