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[Case of primary lymphoplasmacytic lymphoma limited to the paratracheal mediastinum].
[waldenström macroglobulinemia]
A
54
year
old
Japanese
man
was
introduced
to
Saiseikai
General
hospital
for
an
evaluation
of
an
abnormal
chest
X-
ray
film
.
Abnormal
soft
tissue
area
was
observed
in
the
mediastinum
surrounding
anterior
area
of
the
trachea
on
chest
CT
.
Because
the
mediastinal
tumor
showed
slow
enlargement
after
temporal
decrease
and
surgical
resection
of
the
tumor
was
performed
3
years
after
the
first
visit
.
Pathologically
,
diffuse
proliferation
of
oval-shaped
plasmacytic
or
small
lymphocytic
cells
with
eccentrically-located
nuclei
with
rough
chromatin
were
observed
in
the
tumor
.
Immunohistochemically
,
these
cells
were
positive
for
CD
2
0
,
weakly
positive
for
IgM
,
negative
for
CD
3
,
CD
5
,
CD
10
,
suggesting
lymphoplasmacytic
lymphoma
(
LPL
)
.
The
patient
was
treated
with
rituximab
after
the
surgical
treatment
,
and
showed
no
exacerbation
for
3
.
5
years
after
surgery
.
LPL
localized
to
the
paratracheal
mediastinum
is
rare
,
and
a
surgical
approach
is
important
for
prompt
and
proper
diagnosis
.
Diseases
Validation
Diseases presenting
"small lymphocytic cells"
symptom
waldenström macroglobulinemia
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