Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Waldenström macroglobulinemia].
[waldenström macroglobulinemia]
Waldenström
macroglobulinemia
is
a
rare
lymphoproliferative
disease
of
B-
cell
origin
.
These
tumorous
B-
cells
produce
monoclonal
IgM
type
protein
.
Diagnosis
is
based
on
the
detection
of
lymphoplasmacytic
invasion
of
the
bone
marrow
and
serum
electrophoresis
.
Clinical
symptoms
such
as
anemia
,
hyperviscosity
and
neuropathy
are
the
commom
consequences
of
bone
marrow
infiltration
and
serum
monoclonal
IgM
protein
.
Former
use
of
alkylating
agents
are
replaced
by
purine
analogues
,
rituximab
and
bortezomib
.
Additional
clinical
data
have
also
accumulated
regarding
autologous
and
allogenous
stem-cell
transplantation
.
The
authors
present
their
own
clinical
experience
and
give
a
detailed
review
of
current
therapeutic
approaches
.
Orv
.
Hetil
.
,
154
(
50
)
,
1970
-
1974
.
