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Community-acquired infections associated with increased risk of lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia.
[waldenström macroglobulinemia]
Emerging
evidence
supports
the
role
of
immune
stimulation
in
the
development
of
lymphoplasmacytic
lymphoma
/
Waldenström
Macroglobulinaemia
(
LPL
/
WM
)
.
Using
the
population-based
Surveillance
,
Epidemiology
End
Results-
Medicare
database
we
investigated
the
exposure
to
14
common
community-acquired
infections
and
subsequent
risk
of
LPL
/
WM
in
693
LPL
/
WM
cases
and
200
000
controls
.
Respiratory
tract
infections
,
bronchitis
[
odds
ratio
(
OR
)
1
·
56
]
,
pharyngitis
(
OR
1
·
43
)
,
pneumonia
(
OR
1
·
42
)
and
sinusitis
(
OR
1
·
33
)
and
skin
infection
,
herpes
zoster
(
OR
1
·
51
)
were
all
significantly
associated
with
subsequent
increased
risk
of
LPL
/
WM
.
For
each
of
these
infections
,
the
findings
remained
significantly
elevated
following
the
exclusion
of
more
than
6
years
of
Medicare
claims
data
prior
to
LPL
/
WM
diagnosis
.
Our
findings
may
support
a
role
for
infections
in
the
development
of
LPL
/
WM
or
could
reflect
an
underlying
immune
disturbance
that
is
present
several
years
prior
to
diagnosis
and
thereby
part
of
the
natural
history
of
disease
progression
.
