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Steroid profiling in preeclamptic women: evidence for aromatase deficiency.
[aromatase deficiency]
Experimental
data
have
revealed
the
critical
role
played
by
2
-
methoxy-estradiol
,
a
metabolite
of
17
β-estradiol
,
in
the
pathophysiology
of
preeclampsia
.
We
used
gas
chromatography
/
mass
spectrometry
to
measure
a
whole
panel
of
hormonal
steroids
in
the
plasma
from
women
during
the
third
trimester
of
their
pregnancy
.
The
population
study
consists
of
24
pregnant
patients
with
different
outcomes
:
normal
,
or
complicated
by
isolated
preeclampsia
or
by
severe
preeclampsia
with
Hemolysis
Enzyme
Liver
Low
Platelets
(
HELLP
)
syndrome
.
17
β-estradiol
was
reduced
by
50
%
in
isolated
preeclampsia
,
and
by
70
%
in
severe
preeclampsia
with
HELLP
syndrome
(
normal
:
8
.
54
±
0
.
9
ng
/
mL
;
isolated
preeclampsia
:
4
.
65
±
1
.
0
ng
/
mL
;
severe
preeclampsia
with
HELLP
syndrome
:
2
.
64
±
0
.
4
ng
/
mL
)
,
as
is
estrone
.
Downstream
,
2
-
methoxy-estradiol
was
decreased
only
in
severe
preeclampsia
with
HELLP
syndrome
.
The
concentrations
of
estrone
and
17
β-estradiol
precursors
were
comparable
between
groups
,
suggesting
that
placental
aromatase
is
deficient
in
preeclampsia
.
The
gradual
decrease
of
estrogen
levels
with
increasing
severity
of
preeclampsia
suggests
an
impairment
of
placental
steroidogenesis
.
