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Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenström macroglobulinemia.
[waldenström macroglobulinemia]
Waldenström
macroglobulinemia
(
WM
)
is
an
uncommon
lymphoid
malignancy
.
The
characteristics
and
prognosis
of
WM
have
never
been
systematically
studied
in
the
East
.
We
analyzed
the
clinical
characteristics
and
the
prognostic
factors
of
90
Chinese
WM
patients
,
and
compared
them
with
the
Western
reports
.
The
median
age
was
62
years
old
with
a
male-
to
-
female
ratio
of
3
.
74
.
The
most
common
symptoms
at
diagnosis
were
fatigue
(
77
.
8
%
)
and
bleeding
(
20
%
)
,
while
only
6
patients
(
6
.
7
%
)
were
asymptomatic
.
In
the
univariate
analysis
,
age
>
62
years
,
thrombocytopenia
,
leucopenia
,
cytopenias
≥
2
,
and
high
risk
on
the
international
prognostic
scoring
system
for
WM
were
the
adverse
risk
factors
,
but
only
age
>
62
years
and
≥
2
cytopenias
were
the
independent
prognostic
factors
in
the
multivariate
analysis
.
Using
age
<
62
years
and
≥
2
cytopenias
,
three
significantly
different
prognostic
groups
could
been
distinguished
,
with
5
-
year
overall
survival
of
71
.
6
%
,
48
.
6
%
,
and
17
.
0
%
(
P
<
0
.
001
)
.
Distinct
characteristics
exist
in
WM
in
China
compared
to
the
West
and
we
describe
a
new
simple
prognostic
model
for
newly
diagnosed
WM
patients
.
Diseases
Validation
Diseases presenting
"common symptoms"
symptom
allergic bronchopulmonary aspergillosis
hirschsprung disease
scrub typhus
thoracic outlet syndrome
waldenström macroglobulinemia
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