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Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenström macroglobulinemia.
[waldenström macroglobulinemia]
Waldenström
macroglobulinemia
(
WM
)
is
an
uncommon
lymphoid
malignancy
.
The
characteristics
and
prognosis
of
WM
have
never
been
systematically
studied
in
the
East
.
We
analyzed
the
clinical
characteristics
and
the
prognostic
factors
of
90
Chinese
WM
patients
,
and
compared
them
with
the
Western
reports
.
The
median
age
was
62
years
old
with
a
male-
to
-
female
ratio
of
3
.
74
.
The
most
common
symptoms
at
diagnosis
were
fatigue
(
77
.
8
%
)
and
bleeding
(
20
%
)
,
while
only
6
patients
(
6
.
7
%
)
were
asymptomatic
.
In
the
univariate
analysis
,
age
>
62
years
,
thrombocytopenia
,
leucopenia
,
cytopenias
≥
2
,
and
high
risk
on
the
international
prognostic
scoring
system
for
WM
were
the
adverse
risk
factors
,
but
only
age
>
62
years
and
≥
2
cytopenias
were
the
independent
prognostic
factors
in
the
multivariate
analysis
.
Using
age
<
62
years
and
≥
2
cytopenias
,
three
significantly
different
prognostic
groups
could
been
distinguished
,
with
5
-
year
overall
survival
of
71
.
6
%
,
48
.
6
%
,
and
17
.
0
%
(
P
<
0
.
001
)
.
Distinct
characteristics
exist
in
WM
in
China
compared
to
the
West
and
we
describe
a
new
simple
prognostic
model
for
newly
diagnosed
WM
patients
.
Diseases
Validation
Diseases presenting
"fatigue"
symptom
benign recurrent intrahepatic cholestasis
cholangiocarcinoma
congenital adrenal hyperplasia
cowden syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dracunculiasis
erdheim-chester disease
esophageal carcinoma
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
kabuki syndrome
lymphangioleiomyomatosis
neuralgic amyotrophy
pleomorphic liposarcoma
systemic capillary leak syndrome
triple a syndrome
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
x-linked adrenoleukodystrophy
This symptom has already been validated