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Utility of quantitative flow cytometry immunophenotypic analysis of CD5 expression in small B-cell neoplasms.
[waldenström macroglobulinemia]
The
value
of
assessing
CD
5
expression
in
the
differential
diagnosis
of
small
B-
cell
neoplasms
is
well
established
.
Assessment
is
usually
done
qualitatively
.
To
assess
CD
5
expression
levels
by
quantitative
flow
cytometry
immunophenotyping
and
to
determine
possible
differences
among
various
small
B-
cell
neoplasms
.
We
performed
4
-
color
flow
cytometry
analysis
on
specimens
of
peripheral
blood
and
bone
marrow
aspirate
and
quantified
CD
5
expression
in
various
small
B-
cell
lymphomas
and
leukemias
.
We
also
assessed
CD
5
levels
in
peripheral
blood
samples
of
healthy
blood
donors
.
Cases
of
chronic
lymphocytic
leukemia
and
mantle
cell
lymphoma
had
higher
levels
of
CD
5
compared
with
control
B
cells
(
P
<
.
001
)
.
Cases
of
marginal
zone
lymphoma
and
hairy
cell
leukemia
had
CD
5
levels
similar
to
control
B
cells
(
P
=
.
35
and
P
=
.
14
,
respectively
)
,
whereas
cases
of
follicular
lymphoma
and
lymphoplasmacytic
lymphoma
had
significantly
lower
CD
5
levels
than
control
B
cells
(
P
<
.
001
and
P
=
.
04
,
respectively
)
.
In
B-
cell
neoplasms
,
a
high
level
of
CD
5
expression
was
correlated
with
a
homogeneous
pattern
of
positive
events
,
whereas
lower
CD
5
levels
were
correlated
with
heterogeneous
patterns
of
positive
events
.
Using
flow
cytometric
immunophenotypic
analysis
to
quantify
CD
5
levels
can
aid
in
diagnosis
.
CD
5
expression
levels
are
higher
in
patients
with
chronic
lymphocytic
leukemia
and
mantle
cell
lymphoma
,
and
expression
is
observed
in
a
homogeneous
pattern
,
as
compared
with
other
B-
cell
neoplasms
that
are
either
negative
for
CD
5
or
express
CD
5
at
lower
levels
with
a
heterogeneous
pattern
.
However
,
there
is
some
overlap
in
CD
5
expression
levels
between
a
subset
of
atypical
chronic
lymphocytic
leukemia
and
marginal
zone
lymphoma
cases
.
Diseases
Validation
Diseases presenting
"lymphoma"
symptom
adrenal incidentaloma
alpha-thalassemia
carcinoma of the gallbladder
cushing syndrome
dedifferentiated liposarcoma
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
familial hypocalciuric hypercalcemia
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
kabuki syndrome
liposarcoma
locked-in syndrome
monosomy 21
oculocutaneous albinism
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
wiskott-aldrich syndrome
This symptom has already been validated