Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project.

[waldenström macroglobulinemia]

Non-Hodgkin lymphoma (NHL ), the most common hematologic malignancy , consists of numerous subtypes . The etiology of NHL is incompletely understood , and increasing evidence suggests that risk factors may vary by NHL subtype . However , small numbers of cases have made investigation of subtype-specific risks challenging . The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project , an international collaborative effort to investigate the etiologies of NHL subtypes . This article describes in detail the project rationale and design .We pooled individual-level data from 20 case-control studies (17471 NHL cases , 23096 controls ) from North America , Europe , and Australia . Centralized data harmonization and analysis ensured standardized definitions and approaches , with rigorous quality control .The pooled study population included 11 specified NHL subtypes with more than 100 cases : diffuse large B-cell lymphoma (N = 4667 ), follicular lymphoma (N = 3530 ), chronic lymphocytic leukemia /small lymphocytic lymphoma (N = 2440 ), marginal zone lymphoma (N = 1052 ), peripheral T-cell lymphoma (N = 584 ), mantle cell lymphoma (N = 557 ), lymphoplasmacytic lymphoma /Waldenström macroglobulinemia (N = 374 ), mycosis fungoides /Sézary syndrome (N = 324 ), Burkitt /Burkitt-like lymphoma /leukemia (N = 295 ), hairy cell leukemia (N = 154 ), and acute lymphoblastic leukemia /lymphoma (N = 152 ). Associations with medical history , family history , lifestyle factors , and occupation for each of these 11 subtypes are presented in separate articles in this issue , with a final article quantitatively comparing risk factor patterns among subtypes .The International Lymphoma Epidemiology Consortium NHL Subtypes Project provides the largest and most comprehensive investigation of potential risk factors for a broad range of common and rare NHL subtypes to date . The analyses contribute to our understanding of the multifactorial nature of NHL subtype etiologies , motivate hypothesis-driven prospective investigations , provide clues for prevention , and exemplify the benefits of international consortial collaboration in cancer epidemiology .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated