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Multiple lung adenocarcinomas associated with von hippel-lindau disease.
[von hippel-lindau disease]
Lung
adenocarcinoma
has
never
before
been
reported
to
be
associated
with
von
Hippel-
Lindau
(
VHL
)
disease
.
Here
,
we
report
a
case
of
VHL
disease
in
a
patient
who
had
metachronous
multiple
lung
adenocarcinomas
.
The
patient
is
a
64
-
year
-old-woman
with
VHL
disease
.
She
underwent
surgical
resection
of
one
adenocarcinoma
and
one
atypical
adenomatous
hyperplasia
.
A
second
lung
adenocarcinoma
developed
metachronously
.
A
point
mutation
in
the
VHL
gene
was
confirmed
in
DNA
from
a
blood
sample
,
and
loss
of
heterozygosity
at
the
VHL
locus
was
detected
in
the
lung
adenocarcinoma
.
The
VHL
dysfunction
may
have
a
role
in
the
development
of
multiple
lung
adenocarcinomas
.