Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Resistance Patterns of Typhoid Fever in Children: A Longitudinal Community-Based Study.
[typhoid]
Salmonella
typhi
and
S
.
paratyphi
are
important
causes
of
bacteremia
in
children
,
especially
those
from
the
developing
world
.
There
is
a
lack
of
standardized
treatment
protocols
for
such
patients
in
the
literature
,
and
there
are
also
reports
of
therapeutic
failure
related
to
resistance
to
commonly
used
antibiotics
.
We
analyzed
the
epidemiological
,
clinical
,
and
antimicrobiological
sensitivity
patterns
of
disease
in
patients
diagnosed
with
blood
culture-
positive
typhoid
fever
over
a
6
-
month
period
in
a
tertiary-care
pediatric
hospital
in
western
India
.
Data
were
retrospectively
analyzed
for
all
patients
with
Salmonella
isolates
on
blood
culture
between
January
1
and
June
30
,
2011
at
the
Synergy
Neonatal
and
Pediatric
Hospital
.
Susceptibility
of
isolates
to
antimicrobials
and
minimum
inhibitory
concentrations
were
determined
.
Demographic
data
,
symptoms
and
signs
,
basic
laboratory
results
,
treatment
courses
,
and
clinical
outcomes
were
collected
from
clinical
charts
.
All
of
the
61
isolates
of
S
.
typhi
were
sensitive
to
cefepime
(
fourth
-generation
cephalosporin
)
,
96
%
to
third
-generation
cephalosporins
,
and
95
%
to
quinolones
.
There
was
intermediate
sensitivity
to
ampicillin
(
92
%
)
and
chloramphenicol
(
80
%
)
.
Notably
,
azithromycin
resistance
was
observed
in
63
%
of
isolates
.
All
patients
ultimately
made
full
recoveries
.
There
is
an
urgent
need
for
large
scale
,
community-based
clinical
trials
to
evaluate
the
effectiveness
of
different
antibiotics
in
enteric
fever
.
Our
antimicrobial
susceptibility
data
suggest
that
quinolones
and
third
-generation
cephalosporins
should
be
used
as
first
-line
antimicrobials
in
enteric
fever
.
Although
fourth
-generation
cephalosporins
are
useful
,
we
feel
their
use
should
be
restricted
to
complicated
or
resistant
cases
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated