Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Interactome analyses of Salmonella pathogenicity islands reveal SicA indispensable for virulence.
[typhoid]
Serovars
of
Salmonella
enterica
,
namely
Typhi
and
Typhimurium
,
reportedly
,
are
the
bacterial
pathogens
causing
systemic
infections
like
gastroenteritis
and
typhoid
fever
.
To
elucidate
the
role
and
importance
in
such
infection
,
the
proteins
of
the
Type
III
secretion
system
of
Salmonella
pathogenicity
islands
and
two
component
signal
transduction
systems
,
have
been
mainly
focused
.
However
,
the
most
indispensable
of
these
virulent
ones
and
their
hierarchical
role
has
not
yet
been
studied
extensively
.
We
have
adopted
a
theoretical
approach
to
build
an
interactome
comprising
the
proteins
from
the
Salmonella
pathogeneicity
islands
(
SPI
)
and
two
component
signal
transduction
systems
.
This
interactome
was
then
analyzed
by
using
network
parameters
like
centrality
and
k-core
measures
.
An
initial
step
to
capture
the
fingerprint
of
the
core
network
resulted
in
a
set
of
proteins
which
are
involved
in
the
process
of
invasion
and
colonization
,
thereby
becoming
more
important
in
the
process
of
infection
.
These
proteins
pertained
to
the
Inv
,
Org
,
Prg
,
Sip
,
Spa
,
Ssa
and
Sse
operons
along
with
chaperone
protein
SicA
.
Amongst
them
,
SicA
was
figured
out
to
be
the
most
indispensable
protein
from
different
network
parametric
analyses
.
Subsequently
,
the
gene
expression
levels
of
all
these
theoretically
identified
important
proteins
were
confirmed
by
microarray
data
analysis
.
Finally
,
we
have
proposed
a
hierarchy
of
the
proteins
involved
in
the
total
infection
process
.
This
theoretical
approach
is
the
first
of
its
kind
to
figure
out
potential
virulence
determinants
encoded
by
SPI
for
therapeutic
targets
for
enteric
infection
.
A
set
of
responsible
virulent
proteins
was
identified
and
the
expression
level
of
their
genes
was
validated
by
using
independent
,
published
microarray
data
.
The
result
was
a
targeted
set
of
proteins
that
could
serve
as
sensitive
predictors
and
form
the
foundation
for
a
series
of
trials
in
the
wet-lab
setting
.
Understanding
these
regulatory
and
virulent
proteins
would
provide
insight
into
conditions
which
are
encountered
by
this
intracellular
enteric
pathogen
during
the
course
of
infection
.
This
would
further
contribute
in
identifying
novel
targets
for
antimicrobial
agents
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated