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A random Abstract
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Dynamic modularity of host protein interaction networks in Salmonella Typhi infection.
[typhoid]
Salmonella
Typhi
is
a
human-
restricted
pathogen
,
which
causes
typhoid
fever
and
remains
a
global
health
problem
in
the
developing
countries
.
Although
previously
reported
host
expression
datasets
had
identified
putative
biomarkers
and
therapeutic
targets
of
typhoid
fever
,
the
underlying
molecular
mechanism
of
pathogenesis
remains
incompletely
understood
.
We
used
five
gene
expression
datasets
of
human
peripheral
blood
from
patients
suffering
from
S
.
Typhi
or
other
bacteremic
infections
or
non-infectious
disease
like
leukemia
.
The
expression
datasets
were
merged
into
human
protein
interaction
network
(
PIN
)
and
the
expression
correlation
between
the
hubs
and
their
interacting
proteins
was
measured
by
calculating
Pearson
Correlation
Coefficient
(
PCC
)
values
.
The
differences
in
the
average
PCC
for
each
hub
between
the
disease
states
and
their
respective
controls
were
calculated
for
studied
datasets
.
The
individual
hubs
and
their
interactors
with
expression
,
PCC
and
average
PCC
values
were
treated
as
dynamic
subnetworks
.
The
hubs
that
showed
unique
trends
of
alterations
specific
to
S
.
Typhi
infection
were
identified
.
We
identified
S
.
Typhi
infection-
specific
dynamic
subnetworks
of
the
host
,
which
involve
81
hubs
and
1343
interactions
.
The
major
enriched
GO
biological
process
terms
in
the
identified
subnetworks
were
regulation
of
apoptosis
and
biological
adhesions
,
while
the
enriched
pathways
include
cytokine
signalling
in
the
immune
system
and
downstream
TCR
signalling
.
The
dynamic
nature
of
the
hubs
CCR
1
,
IRS
2
and
PRKCA
with
their
interactors
was
studied
in
detail
.
The
difference
in
the
dynamics
of
the
subnetworks
specific
to
S
.
Typhi
infection
suggests
a
potential
molecular
model
of
typhoid
fever
.
Hubs
and
their
interactors
of
the
S
.
Typhi
infection-
specific
dynamic
subnetworks
carrying
distinct
PCC
values
compared
with
the
non-
typhoid
and
other
disease
conditions
reveal
new
insight
into
the
pathogenesis
of
S
.
Typhi
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated