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Review on prescription compatibility of shaoyao gancao decoction and reflection on pharmacokinetic compatibility mechanism of traditional chinese medicine prescription based on in vivo drug interaction of main efficacious components.
[typhoid]
Shaoyao
Gancao
Decoction
(
SGD
)
derived
from
Zhang
Zhongjing
's
"
Typhoid
Theory
"
is
composed
of
peony
and
licorice
,
having
the
efficacy
of
nourishing
liver
,
relaxing
spasm
,
and
relieving
pain
.
Modern
compatibility
studies
of
SGD
on
chemistry
,
pharmacology
,
and
pharmacokinetics
all
demonstrate
the
reasonable
compatibility
of
peony
and
licorice
.
However
,
the
present
research
on
pharmacokinetics
is
only
descriptive
and
limited
to
the
influence
on
in
vivo
dynamic
process
of
certain
ingredients
;
correspondingly
,
there
is
lack
of
studies
on
the
essence
of
these
efficacious
substances
'
in
vivo
changes
;
that
is
,
whether
it
is
because
there
exists
in
vivo
drug
interaction
in
absorption
,
distribution
,
metabolism
,
and
excretion
(
ADME
)
of
active
ingredients
that
leads
to
the
improvement
of
bioavailability
.
We
herein
take
SGD
as
an
example
and
suggest
that
it
is
necessary
to
study
in
vivo
drug
interaction
of
main
efficacious
components
mediated
by
metabolic
enzymes
,
transport
proteins
,
or
plasma
protein
binding
in
the
course
of
ADME
,
which
is
helpful
to
illustrate
the
principle
of
pharmacokinetic
compatibility
from
the
essence
leading
to
the
changes
of
effective
substances
in
vivo
.
Diseases
Validation
Diseases presenting
"pain"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
aniridia
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital diaphragmatic hernia
congenital toxoplasmosis
cushing syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentin dysplasia
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
neuralgic amyotrophy
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
pleomorphic liposarcoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
scrub typhus
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
trochlear dysplasia
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
wolf-hirschhorn syndrome
This symptom has already been validated
