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Comparison between azithromycin and cefixime in the treatment of typhoid fever in children.
[typhoid]
An
intervention
study
was
carried
out
in
the
department
of
paediatrics
of
Mymensingh
Medical
College
Hospital
,
Mymensingh
to
compare
the
clinical
efficacy
of
Azithromycin
in
the
treatment
of
childhood
typhoid
fever
with
that
of
cefixime
for
a
period
of
one
year
from
January
2011
to
December
2011
.
A
total
of
60
cases
of
typhoid
fever
were
enrolled
in
to
a
randomized
clinical
trial
and
was
divided
into
two
groups
.
The
inclusion
criteria
of
the
cases
were
:
Documented
fever
for
more
than
4
days
plus
two
or
more
of
the
following
clinical
features
:
toxic
physical
appearance
,
intestinal
complaints
,
coated
tongue
,
ceacal
gurgling
,
hepatomegaly
and
splenomegaly
,
diarrhoea
and
constipation
plus
positive
Widal
test
and
/
or
blood
culture
positivity
.
Patients
who
had
complication
like
GIT
heamorrhage
;
intestinal
perforaion
and
/
or
shock
were
excluded
from
the
study
.
Data
were
collected
in
a
structured
questionnaire
.
Azithromycin
was
given
at
a
dose
of
10
mg
/
kg
/
day
for
a
period
of
07
days
Cefixime
was
given
at
a
dose
of
20
mg
/
kg
/
day
in
two
divided
dose
for
14
days
.
The
mean
time
of
defervesence
was
4
.
05
+
1
.
14
days
with
azithromycin
and
3
.
41
+
0
.
95
with
cefixime
respectively
.
The
minimum
defervesence
time
was
02
days
and
maximum
defervesence
time
was
07
days
.
Clinical
cure
rate
was
87
%
in
azithromycin
group
and
93
%
in
cefixime
group
.
No
serious
adverse
effect
was
noted
related
to
azithromycin
and
cefixime
therapy
except
nausea
,
vomiting
,
diarrhoea
and
jaundice
.
It
was
found
that
azithromycin
is
almost
as
effective
as
cefixime
in
the
treatment
of
typhoid
fever
.
Diseases
Validation
Diseases presenting
"hepatomegaly"
symptom
carcinoma of the gallbladder
congenital toxoplasmosis
cutaneous mastocytosis
lamellar ichthyosis
neonatal adrenoleukodystrophy
scrub typhus
typhoid
waldenström macroglobulinemia
zellweger syndrome
This symptom has already been validated