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Comparison between azithromycin and cefixime in the treatment of typhoid fever in children.
[typhoid]
An
intervention
study
was
carried
out
in
the
department
of
paediatrics
of
Mymensingh
Medical
College
Hospital
,
Mymensingh
to
compare
the
clinical
efficacy
of
Azithromycin
in
the
treatment
of
childhood
typhoid
fever
with
that
of
cefixime
for
a
period
of
one
year
from
January
2011
to
December
2011
.
A
total
of
60
cases
of
typhoid
fever
were
enrolled
in
to
a
randomized
clinical
trial
and
was
divided
into
two
groups
.
The
inclusion
criteria
of
the
cases
were
:
Documented
fever
for
more
than
4
days
plus
two
or
more
of
the
following
clinical
features
:
toxic
physical
appearance
,
intestinal
complaints
,
coated
tongue
,
ceacal
gurgling
,
hepatomegaly
and
splenomegaly
,
diarrhoea
and
constipation
plus
positive
Widal
test
and
/
or
blood
culture
positivity
.
Patients
who
had
complication
like
GIT
heamorrhage
;
intestinal
perforaion
and
/
or
shock
were
excluded
from
the
study
.
Data
were
collected
in
a
structured
questionnaire
.
Azithromycin
was
given
at
a
dose
of
10
mg
/
kg
/
day
for
a
period
of
07
days
Cefixime
was
given
at
a
dose
of
20
mg
/
kg
/
day
in
two
divided
dose
for
14
days
.
The
mean
time
of
defervesence
was
4
.
05
+
1
.
14
days
with
azithromycin
and
3
.
41
+
0
.
95
with
cefixime
respectively
.
The
minimum
defervesence
time
was
02
days
and
maximum
defervesence
time
was
07
days
.
Clinical
cure
rate
was
87
%
in
azithromycin
group
and
93
%
in
cefixime
group
.
No
serious
adverse
effect
was
noted
related
to
azithromycin
and
cefixime
therapy
except
nausea
,
vomiting
,
diarrhoea
and
jaundice
.
It
was
found
that
azithromycin
is
almost
as
effective
as
cefixime
in
the
treatment
of
typhoid
fever
.
