Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
In vitro modeling of gallbladder-associated Salmonella spp. colonization.
[typhoid]
The
host-pathogen
interactions
occurring
in
the
gallbladder
during
Salmonella
Typhi
colonization
contribute
to
typhoid
fever
pathogenesis
during
the
acute
and
chronic
stages
of
disease
.
The
gallbladder
is
the
primary
reservoir
during
chronic
typhoid
carriage
.
In
this
organ
,
Salmonella
encounters
host-barriers
including
bile
,
immunoglobulins
,
and
mucus
.
However
,
the
bacterium
possesses
mechanisms
to
resist
and
persist
in
this
environment
,
in
part
by
its
ability
to
attach
to
and
invade
into
the
gallbladder
epithelium
.
Such
persistence
in
the
gallbladder
epithelium
contributes
to
chronic
carriage
.
In
addition
,
patients
harboring
gallstones
in
their
gallbladders
have
increased
risk
of
becoming
carriers
because
these
abnormalities
serve
as
a
substrate
for
Salmonella
biofilm
formation
.
Our
laboratory
has
studied
the
Salmonella
interactions
in
this
specific
environment
by
developing
in
vitro
methods
that
closely
mimic
the
gallbladder
and
gallstones
niches
.
These
methods
are
reproducible
and
provide
a
platform
for
future
studies
of
acute
and
chronic
bacterial
infections
in
the
gallbladder
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated