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A random Abstract
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In vitro modeling of gallbladder-associated Salmonella spp. colonization.
[typhoid]
The
host-pathogen
interactions
occurring
in
the
gallbladder
during
Salmonella
Typhi
colonization
contribute
to
typhoid
fever
pathogenesis
during
the
acute
and
chronic
stages
of
disease
.
The
gallbladder
is
the
primary
reservoir
during
chronic
typhoid
carriage
.
In
this
organ
,
Salmonella
encounters
host-barriers
including
bile
,
immunoglobulins
,
and
mucus
.
However
,
the
bacterium
possesses
mechanisms
to
resist
and
persist
in
this
environment
,
in
part
by
its
ability
to
attach
to
and
invade
into
the
gallbladder
epithelium
.
Such
persistence
in
the
gallbladder
epithelium
contributes
to
chronic
carriage
.
In
addition
,
patients
harboring
gallstones
in
their
gallbladders
have
increased
risk
of
becoming
carriers
because
these
abnormalities
serve
as
a
substrate
for
Salmonella
biofilm
formation
.
Our
laboratory
has
studied
the
Salmonella
interactions
in
this
specific
environment
by
developing
in
vitro
methods
that
closely
mimic
the
gallbladder
and
gallstones
niches
.
These
methods
are
reproducible
and
provide
a
platform
for
future
studies
of
acute
and
chronic
bacterial
infections
in
the
gallbladder
.
Diseases
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Diseases presenting
"primary reservoir"
symptom
typhoid
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