Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Acid Exposure Induces Multiplication of Salmonella enterica Serovar Typhi.
[typhoid]
Salmonella
enterica
serovar
Typhi
faces
several
environmental
stresses
while
going
through
the
stomach
(
acidic
pH
)
to
the
small
intestine
(
basic
pH
)
and
intracellularly
in
macrophages
(
acidic
pH
)
in
humans
.
The
acidic
pH
followed
by
alkaline
pH
in
the
small
intestine
might
be
responsible
for
expression
of
certain
stress-induced
genes
,
resulting
in
not
only
better
survival
but
also
induction
of
multiplication
and
invasion
of
the
bacterium
in
the
small
intestine
.
Based
on
this
hypothesis
,
we
developed
a
process
wherein
we
exposed
the
blood
,
urine
,
and
stool
specimens
from
90
acute
typhoid
fever
patients
and
36
chronic
typhoid
carriers
to
acidic
pH
to
see
the
effect
on
isolation
rate
of
S
.
Typhi
.
About
5
g
of
freshly
passed
unpreserved
stool
,
a
centrifuged
deposit
of
15
ml
of
urine
,
and
5
ml
of
blood
clot
were
subjected
to
5
ml
of
Luria-
Bertani
(
LB
)
broth
(
pH
3
.
5
)
for
20
min
,
followed
by
enrichment
in
bile
broth-selenite
F
broth
.
When
the
combined
isolation
from
all
3
specimens
,
i
.
e
.
,
blood
,
urine
,
and
stool
,
after
acid
exposure
was
considered
,
a
total
of
77
.
7
%
of
the
acute
typhoid
patients
were
observed
to
be
positive
for
the
isolation
of
the
S
.
Typhi
serotype
,
compared
to
8
.
8
%
by
the
conventional
method
.
Similarly
,
42
%
(
15
/
36
)
of
chronic
carriers
yielded
positive
for
S
.
Typhi
growth
after
acid
exposure
,
compared
to
5
.
5
%
(
2
/
36
)
by
the
conventional
method
.
It
therefore
can
be
concluded
that
acid
shock
triggers
the
multiplication
of
the
bacteria
,
resulting
in
better
isolation
rates
from
blood
clot
,
stool
,
and
urine
specimens
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated