Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
A novel tool for capture and detection of typhoid fever using Ag-labeled nanocomposites.
[typhoid]
This
work
investigated
a
simple
and
versatile
modification
to
a
solid
substrate
to
develop
antibody
recognition
using
nanoparticles
.
The
new
immobilized
metal
ion
affinity
adsorbent
containing
nanoparticles
and
hydrophilic
resins
is
proposed
here
to
improve
the
binding
of
antigen
on
its
surface
.
The
light-scattering
properties
of
submicroscopic
metal
particles
ranging
from
100
to
120
nm
in
diameter
were
confirmed
by
scanning
electron
microscopy
.
We
found
that
synthesized
nanoparticles
have
an
inherent
enzyme
mimetic
activity
similar
to
that
found
in
natural
peroxidases
.
The
synthesized
nanoparticles
were
coated
with
Salmonella
typhi
and
Salmonella
paratyphi
antigens
and
were
allowed
to
react
with
Salmonella-infected
serum
.
Positive
reactions
were
detected
visually
with
the
naked
eye
.
The
color
changes
of
substrate
(
TMB
)
were
observed
even
in
1
:
800
dilutions
.
This
report
helps
in
developing
a
specific
immunoassay
using
nano
-conjugated
antigen
for
the
rapid
detection
of
S
.
typhi
and
S
.
paratyphi
antibodies
in
infected
serum
.
