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Enteric fever imported to the Czech Republic: epidemiology, clinical characteristics and antimicrobial susceptibility.
[typhoid]
The
aim
of
this
study
was
to
describe
epidemiological
and
clinical
characteristics
of
imported
enteric
fever
in
Czech
travellers
and
to
determine
the
antimicrobial
susceptibility
of
isolated
strains
.
Retrospective
descriptive
study
included
adult
patients
treated
with
enteric
fever
at
Hospital
Na
Bulovce
during
January
2004
-
December
2012
.
A
case
of
typhoid
or
paratyphoid
fever
was
defined
as
isolation
of
Salmonella
Typhi
or
Paratyphi
from
blood
or
stool
.
During
the
study
period
,
there
have
been
diagnosed
19
cases
of
enteric
fever
(
12
males
and
7
females
)
with
age
median
of
30
years
;
14
cases
were
caused
by
Salmonella
Typhi
and
5
cases
by
S
.
Paratyphi
A
.
The
infection
has
been
acquired
in
South
Asia
(
16
patients
;
84
.
2
%
)
,
in
Africa
(
Egypt
,
Angola
)
in
two
cases
(
10
.
5
%
)
,
and
in
Mexico
(
1
;
5
.
3
%
)
.
Symptoms
included
fever
(
all
patients
)
,
diarrhoea
(
16
cases
;
84
.
2
%
)
,
headache
(
9
;
47
.
4
%
)
,
and
abdominal
pain
(
7
;
36
.
8
%
)
.
Seventeen
patients
(
89
.
5
%
)
were
treated
with
fluoroquinolones
;
however
,
the
treatment
failure
was
observed
in
seven
of
them
(
41
.
2
%
)
.
Decreased
ciprofloxacin
susceptibility
was
detected
in
eight
strains
(
66
.
7
%
)
,
and
one
strain
(
8
.
3
%
)
was
multidrug
resistant
.
Sequence
analysis
of
quinolone
resistance-determining
regions
(
QRDR
)
of
the
gyrA
gene
revealed
the
presence
of
amino
acid
substitutions
in
all
tested
isolates
with
decreased
ciprofloxacin
susceptibility
.
Typhoid
and
paratyphoid
fevers
represent
epidemiologically
important
diseases
that
may
lead
to
potentially
life-threatening
complications
.
Major
issue
in
the
management
of
enteric
fever
represents
the
non-
susceptibility
of
Salmonella
strains
to
fluoroquinolones
and
other
antimicrobials
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated
