Rare Diseases Symptoms Automatic Extraction
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Multi-isotype antibody responses against the multimeric Salmonella Typhi hemolysin (HlyE) antigen.
[typhoid]
The
detection
and
measurement
of
different
antibody
isotypes
present
in
the
serum
are
valuable
indicators
of
the
different
stages
of
typhoid
infection
.
Here
,
we
investigated
the
ability
of
S
.
Typhi
HlyE
to
detect
multi-isotype
antibody
responses
in
typhoid
and
paratyphoid
A
patients
'
sera
using
an
indirect
antibody
immunoassay
.
We
found
that
nanogram
levels
of
HlyE
were
sufficient
for
detection
of
IgG
and
IgA
isotypes
and
in
a
study
with
individuals
'
sera
(
n
=
100
)
,
the
immunoassay
was
able
to
distinguish
typhoid
versus
non-
typhoid
sera
.
The
overall
sensitivity
,
specificity
and
efficiency
of
the
ELISA
were
70
%
(
39
/
56
)
,
100
%
(
44
/
44
)
and
83
%
respectively
.
