Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Infectious keratitis after Boston type 1 keratoprosthesis implantation.
[aniridia]
To
determine
the
incidence
,
clinical
features
,
and
outcomes
of
infectious
keratitis
after
Boston
type
1
keratoprosthesis
(
Kpro
)
implantation
.
Ten
cases
of
infectious
keratitis
were
identified
in
a
retrospective
chart
review
of
105
patients
(
126
eyes
)
who
received
Kpro
between
November
2004
and
November
2010
at
the
Cincinnati
Eye
Institute
and
were
followed
for
at
least
1
month
(
range
,
1
-
66
months
;
mean
,
25
months
)
.
The
incidence
was
7
.
9
%
.
Patient
diagnoses
included
4
chemical
injuries
,
3
Stevens-
Johnson
syndrome
,
2
ocular
cicatricial
pemphigoid
,
and
1
congenital
aniridia
.
Kpro
implantation
was
indicated
in
2
eyes
for
a
failed
ocular
surface
and
in
8
for
penetrating
keratoplasty
failure
.
Four
patients
were
contact
lens
intolerant
or
noncompliant
.
All
were
on
topical
vancomycin
and
moxifloxacin
for
prophylaxis
and
2
were
on
topical
amphotericin
for
prophylaxis
.
Three
infiltrates
were
culture
negative
,
5
were
fungal
(
3
Candida
,
1
Fusarium
,
1
Dactylaria
constricta
)
,
and
2
were
bacterial
(
Rhodococcus
equi
and
Gram
-negative
cocci
)
.
All
patients
were
managed
with
topical
agents
and
4
were
given
an
oral
antifungal
agent
.
Four
patients
had
Kpro
removal
with
therapeutic
penetrating
keratoplasty
and
1
had
Kpro
replacement
.
At
final
follow-up
,
only
2
patients
retained
their
preinfection
best
vision
.
Risk
factors
for
infectious
keratitis
included
a
diagnosis
of
cicatrizing
conjunctivitis
(
Stevens-
Johnson
syndrome
,
ocular
cicatricial
pemphigoid
,
or
chemical
injury
)
and
a
history
of
persistent
epithelial
defect
(
P
=
0
.
0003
and
0
.
0142
,
respectively
)
.
Contact
lens
wear
,
vancomycin
use
,
and
a
history
of
systemic
immunosuppression
(
or
use
at
the
time
of
infection
)
were
not
statistically
significant
risk
factors
.
Infectious
keratitis
after
Kpro
can
occur
even
when
patients
are
on
vancomycin
and
a
fourth
-generation
fluoroquinolone
for
prophylaxis
.
Fungal
organisms
are
a
growing
cause
for
concern
,
and
we
present
the
details
of
the
first
reported
case
of
ocular
D
.
constricta
.
The
evolution
of
our
management
and
prophylaxis
strategy
for
fungal
keratitis
after
Kpro
implantation
is
also
described
.
Diseases
Validation
Diseases presenting
"first reported case"
symptom
achondroplasia
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
aniridia
cutaneous mastocytosis
dedifferentiated liposarcoma
epidermolysis bullosa simplex
fabry disease
focal myositis
harlequin ichthyosis
heparin-induced thrombocytopenia
kabuki syndrome
malignant atrophic papulosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
pleomorphic liposarcoma
primary hyperoxaluria type 1
thoracic outlet syndrome
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wolf-hirschhorn syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom